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What are the implications of the case study for future research?
What are the implications of the case study for future research? {#sec1} ========================================================= The use of in vitro models for neurological research has been instrumental in a range of areas including the development, understanding, and treatment of diseases, as well as neuroengineering ([@bib34]). While the field of regenerative dentistry has shown steady progress in the ability to regenerate damaged dentition over the years, it has yet to make significant advances in the treatment of cerebrovascular disease or neurodegenerative disease ([@bib23]). However, we believe that by constructing a patient specific in vitro model, which retains molecular features of both the diseased areas in a patient\’s brain and their existing blood vessels and other neurovascular structures, the patient\’s own cells (or derived ones, such as those from stem cell sources), as well as biomaterials, could be used to reconstruct the damaged area with human regeneration. Ultimately, achieving this goal will lead to a more accurate and detailed understanding of how the regeneration occurs, thus allowing greater improvements to be made over time. What other questions should readers take away from this publication? {#sec2} =================================================================== The findings from this study show that specific biomaterials can be engineered to effectively maintain the stem cells while they are growing on those respective biomaterials. The studies also suggest that over time, the stem cells actively follow the growth and structural changes happening within the underlying biomaterial through an adhesive-dependent process. What current or future trends will shape this field? {#sec3} =================================================== Although much research is still required before meaningful medical outcomes can be achieved, the rise in recent years of neuroregenerative approaches in vivo has led to a renewed interest in the effective translation of these approaches into the clinic ([@bib3], [@bib7], [@bib43]) over the coming years. In fact, patient-derived stem cells from various sources, including bone marrow, blood, fat, and dental stem cells, have been tested successfully in preclinical and clinical trials, taking advantage of the intrinsic permissiveness of their tissues for tissue regeneration ([@bib1], [@bib18], [@bib46], [@bib44], [@bib45]). It is therefore expected that these therapies will receive the development needed over the course of our lifetimes. {What are the implications of the case study for future research? In this study, we evaluated the effect of a brief intervention for improving screening rates among veterans for both prostate-specific antigen (PSA) and PSA-free (PSA-F) tests. Methods {#s1} ======= This brief intervention was implemented in three Veterans Health Administration (VHA) sites in southern California between October 2014 and December 2014. The VHA is the largest integrated provider of medical and mental health care in the United States, consisting of a network of more than 330 community-based outpatient care sites, 1,200 community based medical facility sites, approximately 40 hospitals and 3832 community find here nursing homes. ^a^ During this time period, participating Veterans Affairs (VA) Community-Based Outpatient Health Centers had an average of 45,721 male veterans each month. Men participating in this study had been enrolled at least 3 months prior to the 10:00 am census. All sites used pharmacy data as of the 10:00 am census to generate lists of men with prescriptions. The participants were mailed an information letter by mail directly from the study team following the 10:00 am census, in addition to being provided printed materials on PSA and PSA-F screenings and prostate cancer. A brief informed consent was completed by mail about the study. Men that declined were contacted on another day within the week by phone to find out why they did not want the service. Men who filled a pharmacy prescription during the 10:00 am through 23:59 pm census were included in the study. Men that were prescribed medication for depression, erectile or stress conditions or on stable doses of antidepressants were excluded. Two-step sampling was used to select the men. Through the use of the pharmacy data, the teams identified men that were prescribed PSA and PSA-F once between May 15 and July 30.
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This time window chose for historical reasons to reduce the variation associated with testing schedules over the course of the year. Men were then sorted into the categories requested by the VHA based on their prescription. For this study, we received approval for a quasi-systematic prospective design assessing a brief intervention to improve our screening rates. ^b^ The study was approved by the University of Southern California Institutional Review Board (approval 13-0071 F), and the VHA Institutional Review Board (IRB \#1659-0288) approved the research. Additionally, the VHA Research and Development Committee approved the letter of support for this research. A community healthcare center in Los Angeles, a VA health center in Lorman, and a VA home health care site in Ventura also received the same intervention. Community healthcare center targets were the Veterans Affairs Community Living Centers and Care Coordination outpatient services. Additionally, this site provided prostate cancer screening to older veterans who were transferred into the VA from long term care. The Lorman service provided primary health care, mental What are the implications of the case study for future research?**There is a clear need to explore the ways in which trust is generated within social support relationships as it appears that social support, including trust, is important to people with a mental illness. The literature suggests that a trusted relationship improves the ways in which people with a mental illness cope with their illness, in some cases better than medication does. This could be a key focus for future research on mental health. What are the implications of the case study for clinical practice and/or policy?For people with mental illness who attend a mainstream mental health service, receiving support from a healthcare professional which is more trusting and caring than others may improve their mood and wellbeing accordingly. If people with a mental illness seek help from professionals they are aware of, they may not have trust issues to that they do not receive the same respect from those in recovery meetings.
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A-G was supported by a postdoctoral fellowship from the Society for Mental Health Research, Northumbria University and the Marie Curie Cancer Care Trust. Competing interests {#s20019} =================== The authors have declared that no competing interests exist. Authors’ contributions {#s20020} ====================== A-G was the primary author and was responsible for the literature review approach that went into the manuscript. All authors contributed to the writing. Funding information {#s20021} =================== Funding was received from the Society for Mental Health and Marie Curie Cancer Care Trust. Data availability statement {#s20022} =========================== Data sharing is not possible as a PhD was the sole form of output. Disclaimer {#s20023} ========== The views expressed in this paper are those of the authors alone and not those of the Society for Mental Health Research or Marie Curie Cancer Care Trust. **How to cite this article:** Green, A-G